Only tryptophan hydroxylase (TPH)-2 is relevant to the CNS

C1473G polymorphism in mouse tph2 gene i

C1473G polymorphism in mouse tph2 gene is linked to tryptophan hydroxylase-2 activity in the brain, intermale aggression, and depressive-like behavior in the forced swim test

✍ Daria V. Osipova; Alexander V. Kulikov; Nina K. Popova 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 173 KB

## Abstract Tryptophan hydroxylase‐2 (TPH2) is the rate‐limiting enzyme of brain serotonin synthesis. The C1473G polymorphism in the mouse tryptophan hydroxylase‐2 gene affects the enzyme's activity. In the present study, we investigated the linkage between the C1473G polymorphism, enzyme activity