𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Online Hydrogen/Deuterium Exchange Performed in the Ion Mobility Cell of a Hybrid Mass Spectrometer

✍ Scribed by Nagy, Kornél; Redeuil, Karine; Rezzi, Serge

Book ID
125539938
Publisher
American Chemical Society
Year
2009
Tongue
English
Weight
493 KB
Volume
81
Category
Article
ISSN
0003-2700

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Gas phase hydrogen/deuterium exchange re
Gas phase hydrogen/deuterium exchange reactions of peptide ions in a quadrupole ion trap mass spectrometer
✍ Igor A. Kaltashov; Vladimir M. Doroshenko; Robert J. Cotter 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 93 KB 👁 2 views

Hydrogen/deuterium exchange reactions of protonated and sodium cationized peptide molecules have been studied in the gas phase with a MALDI / quadrupole ion trap mass spectrometer. Unit-mass selected precursor ions were allowed to react with deuterated ammonia introduced into the trap cell by a puls

Rapid identification of phase I and II m
Rapid identification of phase I and II metabolites of artemisinin antimalarials using LTQ-Orbitrap hybrid mass spectrometer in combination with online hydrogen/deuterium exchange technique
✍ Tian Liu; Fuying Du; Yakun Wan; Fanping Zhu; Jie Xing 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 226 KB

## Abstract Artemisinin drugs have become the first‐line antimalarials in areas of multi‐drug resistance. However, monotherapy with artemisinin drugs results in comparatively high recrudescence rates. Autoinduction of CYP‐mediated metabolism, resulting in reduced exposure, has been supposed to be t

Structural characterization of in vitro
Structural characterization of in vitro rat liver microsomal metabolites of antihistamine desloratadine using LTQ-Orbitrap hybrid mass spectrometer in combination with online hydrogen/deuterium exchange HR-LC/MS
✍ Guodong Chen; Ibrahim Daaro; Birendra N. Pramanik; John J. Piwinski 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 216 KB

## Abstract __In vitro__ drug metabolism study is an integral part of drug discovery process. In this report, we have described the application of LTQ‐Orbitrap hybrid mass spectrometer in conjunction with online hydrogen (H)/deuterium (D) exchange high resolution (HR)‐LC/MS for structural character

Structural identification of trace level
Structural identification of trace level enol tautomer impurity by on-line hydrogen/deuterium exchange HR-LC/MS in a LTQ-Orbitrap hybrid mass spectrometer
✍ Dr Guodong Chen Guodong Chen; Anatoliy Khusid; Ibrahim Daaro; Patrick Irish; Bir 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 165 KB

Structural identification of trace level enol tautomer impurity by on-line hydrogen/deuterium exchange HR-LC/MS in a LTQ-Orbitrap hybrid mass spectrometer With advancements in ionization methods and instrumentation, liquid chromatography/mass spectrometry (LC/MS) has become a powerful technology for