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One-step synthesis of α-hydroxy-α-azinylcyanoacetic esters from α-nitro derivatives of α-azinylcyanoacetic esters

✍ Scribed by I. V. Oleinik; O. P. Shkurko


Book ID
105596205
Publisher
Springer
Year
1997
Tongue
English
Weight
238 KB
Volume
46
Category
Article
ISSN
1573-9171

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✍ Johan Legters; Erik van Dienst; Lambertus Thijs; Binne Zwanenburg 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 716 KB

## Abstract 3‐Aryl‐3‐azido‐2‐hydroxypropanoic esters, prepared from the corresponding 3‐aryl‐oxirane‐2‐carboxylic esters by ring opening with sodium azide, were reduced with tin(II) chloride dihydrate in methanol to give 3‐amino‐3‐aryl‐2‐hydroxypropanoic esters in good yields. Under these condition