One-step synthesis of 4(3H)-quinazolinones

✍ Scribed by Martin J Deetz; Jeremiah P Malerich; Alicia M Beatty; Bradley D Smith

• Book ID: 104230174
• Publisher: Elsevier Science
• Year: 2001
• Tongue: French
• Weight: 103 KB
• Volume: 42
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)00096-x

✦ Synopsis

2-Fluoro substituted benzoyl chlorides undergo cyclocondensation with 2-amino-N-heterocycles to form 4(3H)-quinazolinones. The reaction proceeds in moderate yields with different combinations of benzoyl chlorides and 2-amino-N-heterocycles. The products generally precipitate from the reaction mixture and require no further purification. Two tetrafluoro quinazolinones were found to be moderately active against a number of tumor cell lines.