One-Step Immobilization of Protein-Encapsulated Core/Shell Particles onto Nanofibers

✍ Scribed by Chul Ho Park; Jonghwi Lee

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 332 KB
• Volume: 295
• Category: Article
• ISSN: 1438-7492
• DOI: 10.1002/mame.201000039

✦ Synopsis

Abstract

A novel method is described to functionalize nanofibers to form a nanocomposite with core/shell particles in order to control protein release. The nanocomposite is produced by electrically neutralizing negatively charged poly(lactic acid) nanofibers with positively charged poly[(lactic acid)‐co‐(glycolic acid)] particles via a one‐step electrohydrodynamic jetting process. The protein‐encapsulated core/shell particles exhibited no significant initial burst release or denaturation. The protein release profile was controlled by porosity and protein/polymer interactions. The method may be promising to engineer intelligent scaffolds that can fulfill the needs of biomimetic materials.

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