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One-sided tests in generalized linear dose–response models

✍ Scribed by Gilberto A. Paula

Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
142 KB
Volume
30
Category
Article
ISSN
0167-9473

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✦ Synopsis

This paper discusses the asymptotic null distribution of three asymptotically equivalent one-sided tests in generalized linear models with separate lines. Simple forms for the correlation coe cients, which appear in the weights of the asymptotic null distribution, that is a mixture of chi-squared distributions, are given. A particular structure is proposed for the experiments in order to simplify the correlations and consequently to allow the use of several approximations developed for the weights. It is showed that the hypothesis of synergism or antagonism between two compounds may be assessed, under parallelism, by one-sided tests. Finally, as illustration, the e ciency of a standard preparation is compared with the e ciency of four test preparations under a gamma log-linear model.

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