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One-pot, three-component synthesis of 2,3-dihydroquinazolin-4(1H)-ones usingp-toluenesulfonic acid–paraformaldehyde copolymer as an efficient and reusable catalyst

✍ Scribed by Ali Saffar-Teluri; Shiva Bolouk


Book ID
106214540
Publisher
Springer Vienna
Year
2010
Tongue
English
Weight
168 KB
Volume
141
Category
Article
ISSN
0026-9247

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Silica sulfuric acid efficiently catalyzes the three-component Biginelli reaction between an aldehyde, a b-dicarbonyl compound and urea or thiourea in refluxing ethanol to afford the corresponding dihydropyrimidinones in high yields. The catalyst is reusable and can be applied several times without