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One-pot synthesis of β-imidazolylpropionamides

✍ Scribed by Sergey V. Ryabukhin; Dmitry S. Granat; Pavel V. Khodakovskiy; Alexander N. Shivanyuk; Andrey A. Tolmachev

Publisher
Elsevier Science
Year
2008
Tongue
French
Weight
153 KB
Volume
49
Category
Article
ISSN
0040-4039

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✦ Synopsis

New efficient one-pot methodology for the preparative synthesis of b-imidazolylpropionamides was elaborated. It is based on the addition of imidazole to the activated double bond of the intermediate acrylimidazolide in the reaction between diverse acrylic acids and different amines promoted by CDI. A set of structurally and functionally diverse b-imidazolylpropionamides was obtained in high preparative yields.

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