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One-Pot Synthesis of Pyrimidine-5-Carboxaldehyde and Ethyl Pyrimidine-5-Carboxylate by Utilizing Pyrimidin-5-yl-Lithium

โœ Scribed by Rho, Taikyun; Abuh, Yahaya F.


Book ID
111694635
Publisher
Taylor and Francis Group
Year
1994
Tongue
English
Weight
164 KB
Volume
24
Category
Article
ISSN
0039-7911

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Synthesis of 5,6-bis(alkyn-1-yl)pyrimidi
โœ E.Sathyajith Kumarasinghe; Matt A Peterson; Morris J Robins* ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 88 KB

Sonogashira coupling of 5-iodo-1-methyluracil or 5%-O-TBDMS-5-iodo-2%,3%-O-isopropylideneuridine with alkynes gave 5-(alkyn-1-yl) derivatives that underwent 6-lithiation/iodination to give 5-(alkyn-1-yl)-6iodo-(1-methyluracil or uridine) intermediates (57-80%). Coupling of the 5-(alkyn-1-yl)-6-iodo