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One-pot synthesis of dihydropyrimidinones catalysed by lithium bromide: an improved procedure for the Biginelli reaction

✍ Scribed by Gourhari Maiti; Pradip Kundu; Chandrani Guin

Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 79 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)02859-9

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✦ Synopsis

LiBr catalyses efficiently the three component condensation reaction of an aldehyde, a b-ketoester and urea in refluxing acetonitrile to afford the corresponding dihydropyrimidinones in high yield.

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