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One-pot synthesis of aryl glycines and other unnatural amino acids from serine derivatives

✍ Scribed by Alicia Boto; Rosendo Hernández; Adriana Montoya; Ernesto Suárez


Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
94 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis


A mild and highly efficient one-pot synthesis of aryl glycines from easily available serine derivatives is described. This methodology is also applied to the synthesis of other uncommon amino acids.


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Proline, 4-hydroxyproline, azetidine-2-carboxylic acid, pipecolic acid and proline containing dipeptides were converted to N-t-butyloxycarbonyl, 0-phenacyl derivatives in a one pot synthesis. 'H-and 13C-NMR spectroscopy of certain derivatives (Boc-Pro-PE, Boc-4Hyp-PE, Boc-Pro-4BrPE and Boc-Pip-PE) i