One-Pot Synthesis of Antigen-Bearing, Lysine-Based Cluster Mannosides Using Two Orthogonal Chemoselective Ligation Reactions

✍ Scribed by Cyrille Grandjean; Corinne Rommens; Hélène Gras-Masse; Oleg Melnyk

• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 174 KB
• Volume: 112
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/(sici)1521-3757(20000317)112:6<1110::aid-ange1110>3.0.co;2-8

✦ Synopsis

Dendritic cells (DCs) are well-recognized for playing a crucial role in the control of immunity. These professional antigen-presenting cells act both as initiators and modulators dimensions 0.5 Â 0.25 Â 0.10 mm 3 . A total of 8840 reflections were collected at À 90 8C using a Siemens diffractometer equipped with a CCD detector in the q range of 1.72 to 20.008, of which 2788 were unique (R int 0.0570). The structure was solved by the Patterson heavy atom method in conjunction with standard difference Fourier techniques. Hydrogen atoms were placed in calculated positions using a standard riding model and were refined isotropically. A methanol solvent molecule was found to be disordered and was modeled by standard procedures. The largest peak and hole in the difference map were 0.957 and À 0.424 e À3 , respectively. The least-squares refinement converged normally giving residuals of R 0.0749 and wR 2 0.1983. Crystallographic data (excluding structure factors) for the structure reported in this paper have been deposited with the Cambridge Crystallographic Data Centre as supplementary publication no. CCDC-133672. Copies of the data can be obtained free of charge on application to CCDC,