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One-Pot Synthesis of 4,5-Dihydro-3,1-benzoxazepine-2(1H)-thiones from 2-(2-Isocyanophenyl)ethanols via the Corresponding Isothiocyanates

โœ Scribed by Kobayashi, Kazuhiro; Fukamachi, Shuhei; Konishi, Hisatoshi


Book ID
118272872
Publisher
Japan Institute of Heterocyclic Chemistry
Year
2011
Tongue
English
Weight
632 KB
Volume
83
Category
Article
ISSN
0385-5414

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One-Pot Synthesis of 2-Substituted 4-Ary
โœ Shuhei Fukamachi; Hisatoshi Konishi; Kazuhiro Kobayashi ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› John Wiley and Sons ๐ŸŒ German โš– 149 KB

An efficient method for the preparation of 2-substituted 4-aryl-4,5-dihydro-3,1-benzoxazepine derivatives under mild conditions has been developed. The reaction of 2-(2-aminophenyl)ethanols 1 with acid chlorides in the presence of excess Et 3 N in THF at room temperature gave the corresponding Nacyl