One-pot synthesis of 2,3-disubstituted-2,3-dihydroquinazolin-4(1H)-ones using [Hmim][NO3]: An eco-friendly protocol

✍ Scribed by Iraj Mohammadpoor-Baltork; Ahmad Reza Khosropour; Majid Moghadam; Shahram Tangestaninejad; Valiollah Mirkhani; Mohammad Soltani; Arsalan Mirjafari

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2011
• Tongue: English
• Weight: 513 KB
• Volume: 48
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.721

✦ Synopsis

Abstract

An efficient method for the synthesis of a series of 2,3‐disubstituted‐2,3‐dihydroquinazolin‐4(1H)‐ones is described via one‐pot condensation reaction of isatoic anhydride, aryl aldehydes, and primary amines using a Brønsted acidic ionic liquid, [Hmim][NO~3~], as a catalyst and medium. The present protocol enjoys convenient reaction and simple work‐up, greenness, short reaction times, and reusable catalyst as well as mild reaction conditions. J. Heterocyclic Chem., (2011).