One-Pot Synthesis of 2-Imidazolines via the Ring Expansion of Imidoyl Chlorides with Aziridines
β Scribed by Kuszpit, Michael R.; Wulff, William D.; Tepe, Jetze J.
- Book ID
- 111672464
- Publisher
- American Chemical Society
- Year
- 2011
- Tongue
- English
- Weight
- 900 KB
- Volume
- 76
- Category
- Article
- ISSN
- 0022-3263
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A novel tandem one-pot method for the synthesis of a-aminomethylene-c-butyrolactone derivatives has been developed through the regioselective epoxide opening reactions with the Blaise reaction intermediates, generated by the reaction of a Reformatsky reagent with nitriles. Formation of a modified Bl
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## Abstract An efficient and practical synthetic method has been developed for the preparation of symmetrical diarylacetylenes from the direct reaction of aryl chlorides with 2βmethylβ3βbutynβ2βol catalyzed by palladium(II) chlorideβbis(tricyclohexylphosphine) [PdCl~2~(PCy~3~)~2~] under mild reacti