One-Pot Synthesis of 1,4-Dihydro-2-thioxo-2H-3,1-benzoxazine-4-acetic Acid Derivatives by the Reaction of 2-Isothiocyanatophenyl Ketones with Lithium Enolates of Acetates and Tertiary Acetamides
✍ Scribed by Kazuhiro Kobayashi; Shuhei Fukamachi; Akihiro Kobayashi; Aogu Gotoh
- Book ID
- 115556370
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- German
- Weight
- 153 KB
- Volume
- 95
- Category
- Article
- ISSN
- 0018-019X
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## Abstract Two efficient methods for the preparation of 2‐(2‐sulfanyl‐4__H__‐3,1‐benzothiazin‐4‐yl)acetic acid derivatives **3** under mild conditions have been developed. The first method is based on the reaction of 3‐(2‐isothiocyanatophenyl)prop‐2‐enoates **1a**–**1c** with thiols in the presenc