✦ LIBER ✦
One-pot stereoselective synthesis of dimethanodibenzo[e,i][1,4]diazecines by a zinc-acetic acid promoted cascade reaction
✍ Scribed by Christelle Podevin; Micheline Grignon-Dubois; Gladys Nuissier; Jean-Christophe Gauffre; Bernadette Rezzonico
- Book ID
- 104209501
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 837 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0040-4020
No coin nor oath required. For personal study only.
✦ Synopsis
The title compounds arc intcrcstiug C> s\nunctric:ll dkm~incs. Thcy uerc prcpared in a one-pot process by reacting quinaldines \vith a zinc-ncctic acid misturc in THF solution. During this simple and slcrcoselectivc process, twvo C-C bonds and 4 stercogcnic centrcs nrc crcntcd undcr mild conditions. hlluc~m of thc concentration of reapnts upon yields aod intrztmolccular cyclkition rcgiochcmistry is dcmonslrntcd. Espcrimcnts using dcukrialed acctic acid allowved a good understanding of IIICSC rcsuhs.