One-Pot Stereoselective Synthesis of anti 3-Alkyl and 3-Aryl-N-p-tosyl-aziridine-2-ketones and 3-Aryl-N-p-tosyl-aziridine-2-carboxylates.

✍ Scribed by Dianjun Chen; Cody Timmons; Li Guo; Xin Xu; Guigen Li

• Publisher: John Wiley and Sons
• Year: 2005
• Weight: 42 KB
• Volume: 36
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.200511121

✦ Synopsis

Aziridine derivatives R 0040

One-Pot Stereoselective Synthesis of anti 3-Alkyl and 3-Aryl-N-p-tosyl-aziridine--2-ketones and 3-Aryl-N-p-tosyl-aziridine-2-carboxylates. -A practical one-pot protocol for the synthesis of N-tosyl-aziridine-2-carboxylates and ketones following the different reaction conditions presented is described. The synthesis proceeds through aminohalogenation and subsequent SN2 cyclization. -(CHEN, D.; TIMMONS, C.;