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One-pot solvent and catalyst-free synthesis of functionalized 1,8-naphthyridines and quinolines by microwave irradiation

✍ Scribed by Shyamaprosad Goswami; Subrata Jana; Anita Hazra; Avijit Kumar Adak

Publisher
Journal of Heterocyclic Chemistry
Year
2007
Tongue
English
Weight
245 KB
Volume
44
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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A series of functionalized, aryl substituted naphthyridines and quinolines has been synthesized by microwave‐assisted one‐pot two‐component synthesis under solvent‐free conditions in good yields by the reaction of a variety of aryl or heteroaryl amines and aryl vinyl ketones. A combinatorial type approach for a one‐step microwave reaction has been developed where a ring‐closing condensation is followed by a spontaneous aromatization to afford the functionalized aryl substituted 1,8‐naphthyridines and quinolines.

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