One-pot sequential glycosylation:A new method for the synthesis of branched oligosaccharides
β Scribed by Haruo Yamada; Tetsuya Kato; Takashi Takahashi
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 223 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
One-pot glycosylations of glycosyl bromides and phenylthio glycosides with various dihydroxyl glycosyl acceptors have been examined to provide the corresponding branched trisaccharides.
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2,3,6,2',3',4',6'-Hepta-O-methylmaltose diethyl dithioacetal (2), obtained under mild conditions from N-methyl-hepta-O-methyl-N-p-nitrophenyl-beta-maltosylamine (1), was converted into the disulfone 4. Storage of a solution of 4 in aqueous tetrahydrofuran gave 1,2-dideoxy-1,1-bis(ethylsulfonyl)hepta