๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

One-pot-one-step, microwave-assisted Fischer indole synthesis

โœ Scribed by Evelyn Cuevas Creencia; Masayuki Tsukamoto; Takaaki Horaguchi

Publisher
Journal of Heterocyclic Chemistry
Year
2011
Tongue
English
Weight
174 KB
Volume
48
Category
Article
ISSN
0022-152X

No coin nor oath required. For personal study only.

โœฆ Synopsis

Abstract

The Fischer indole synthesis was carried out using microwaves instead of conventional heating procedures. When the mixture of phenylhydrazine, cyclohexanone and zinc chloride was irradiated at 600 W for 3 min, 76% of 1,2,3,4โ€tetrahydrocarbazole was obtained. However, when zinc chloride was replaced with pโ€toluenesulfonic acid (pโ€TSA), the reaction yielded 91% of 1,2,3,4โ€tetrahydrocarbazole. Thus, a series of indoles were prepared using microwaves in the presence of pโ€TSA catalyst. J. Heterocyclic Chem., (2011).

๐Ÿ“œ SIMILAR VOLUMES

Microwave-Assisted One-Pot Synthesis of
Microwave-Assisted One-Pot Synthesis of 1,2,3,4-Tetrahydrocarbazoles.
โœ Jing Chen; Yongzhou Hu ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons โš– 17 KB ๐Ÿ‘ 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Microwave-Assisted One-Step High-Through
Microwave-Assisted One-Step High-Throughput Synthesis of Benzimidazoles.
โœ Shou-Yuan Lin; Yuko Isome; Ethan Stewart; Ji-Feng Liu; Daniel Yohannes; Libing Y ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons โš– 25 KB ๐Ÿ‘ 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.