✦ LIBER ✦
‘One-pot’ nitro reduction–cyclisation solid phase route to benzimidazoles
✍ Scribed by Zemin Wu; Philip Rea; Geoffrey Wickham
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 65 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
An improved solid phase synthesis of benzimidazoles is described. A polymer-bound o-nitroaniline was reacted with aldehydes in DMF in the presence of SnCl 2 •2H 2 O at 60°C for three hours to give benzimidazoles in excellent purity and good yield after TFA cleavage. A library of 25 benzimidazoles was prepared using this 'one-pot' procedure.