One-phase solvent systems for paper chromatography. Mixtures of N-butanol, acetic acid, and water
✍ Scribed by T. J. Betts
- Publisher
- John Wiley and Sons
- Year
- 1964
- Tongue
- English
- Weight
- 380 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0022-3549
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✦ Synopsis
out exception, the carboxylic acid polymers (acrylic and maleic acids), demonstrated the most potential as prolonged-action coatings based on solubility in simulated gastric and intestinal fluids. Solubility of a maleic acid polymer varied in aqueous media at a range of pH levels with the degree of esterification of the polymer and with the ester chain length. Butyl half esters of the maleic acid polymer demonstrated good potential sohtbility properties for a prolonged-action coating. The intact films studied were impermeable to drug in solution. Polymerdrug binding was significant with only one of the three final polymers studied Poly(methy1 vinyl ether)/maleic anhydride n-butyl half ester demonstrated the best in oitro potential as a sustained-Journal of Pharmaceutical Sciences action coating. The polymer showed no toxic effects in a preliminary short-term feeding study.