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One INK4 gene and no ARF at the Fugu equivalent of the human INK4A/ARF/INK4B tumour suppressor locus

✍ Scribed by Gilley, Jonathan; Fried, Mike


Book ID
110066166
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
233 KB
Volume
20
Category
Article
ISSN
0950-9232

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Chromosome 9p21 is frequently deleted in malignant melanoma, and one familial malignant melanoma gene has been linked to 9p21-22. Recently, the cyclin D-dependent kinase inhibitors (CDKIs) p16INK4a and p15INK4b have been localized within chromosome 9p21, and the presence of p16INK4a point mutations