PTEN: One Gene, Many Syndromes
✍
Charis Eng
📂
Article
📅
2003
🏛
John Wiley and Sons
🌐
English
⚖ 217 KB
## Communicated by Christopher Mathew PTEN, on 10q23.3, encodes a major lipid phosphatase which signals down the phosphoinositol-3-kinase/Akt pathway and effects G1 cell cycle arrest and apoptosis. Germline PTEN mutations have been found to occur in 80% of classic Cowden syndrome (CS), 60% of Banna