One- and two-dimensional gradient-selected HSQMBC NMR experiments for the efficient analysis of long-range heteronuclear coupling constants
✍ Scribed by R. Thomas Williamson; Brian L. Márquez; William H. Gerwick; Katalin E. Kövér
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 240 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0749-1581
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✦ Synopsis
Three new gradient-selected NMR experiments for the analysis of long-range heteronuclear coupling constants are presented. They are demonstrated on a series of compounds including sucrose, strychnine and a complex macrolide, phormidolide, isolated from a marine cyanobacterium. These 1D and 2D heteronuclear single quantum multiple bond correlation (HSQMBC) experiments provide pure absorption, antiphase lineshapes for precise, direct measurement of n J(C,H) coupling constants. The example compounds were chosen to demonstrate the high sensitivity and ease of spectral interpretation provided by these HSQMBC experiments. In addition, suppression of one-bond CH correlations has been introduced into the HSQMBC pulse sequence.