Oncostatin M, a member of IL-6 family cytokines, induces MMP-9 expression and activation in vascular smooth muscle cells via ERK-mediated pathway

ERK1/2 mediates TNF-α-induced matrix met

ERK1/2 mediates TNF-α-induced matrix metalloproteinase-9 expression in human vascular smooth muscle cells via the regulation of NF-κB and AP-1: Involvement of the ras dependent pathway

✍ Sung-Kwon Moon; Byung-Yoon Cha; Cheorl-Ho Kim 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 386 KB 👁 1 views

## Abstract The expression of matrix metalloproteinase‐9 (MMP‐9) has been implicated in progression of atherosclerotic lesions. The role and importance of the signaling pathway in the transcriptional regulation of MMP‐9 in human aortic smooth muscle cells (HASMC) was examined. Tumor necrosis factor