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Oncolytic virotherapy with modified adenoviruses and novel therapeutic targets

✍ Scribed by Halldén, Gunnel; Portella, Giuseppe

Book ID
115438922
Publisher
Informa plc
Year
2012
Tongue
English
Weight
357 KB
Volume
16
Category
Article
ISSN
1472-8222

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## Abstract The safety of oncolytic viruses for treatment of cancer has been shown in clinical trials while antitumor efficacy has often remained modest. As expression of the coxsackie‐adenovirus receptor may be variable in advanced tumors, we developed Ad5‐D24‐RGD, a p16/Rb pathway selective oncol