𝔖 Bobbio Scriptorium
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Oncolytic herpes simplex virus vectors for cancer virotherapy

✍ Scribed by Varghese, Susan; Rabkin, Samuel D

Book ID
110018957
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
422 KB
Volume
9
Category
Article
ISSN
0929-1903

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## SUMMARY Oncolytic viruses infect, replicate in and kill cancer cells. HSV has emerged as a most promising candidate because it exerts a generally moderate pathogenicity in humans; it is amenable to attenuation and tropism retargeting; the ample genome provides space for heterologous genes; speci

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## Abstract ## Background Tumour necrosis factor alpha (TNFΞ±) therapy is a promising anti‐cancer treatment when combined with radiotherapy due to its potent radio sensitising effects, but systemic toxicity has limited its clinical use. Previously, non‐replicative adenovirus vectors have been used