Oncological outcome of ultra-low coloanal anastomosis with and without intersphincteric resection for low rectal adenocarcinoma (Br J Surg 2007; 94: 341–345)

✍ Scribed by C. R. Selvasekar; I. Hassan

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 56 KB
• Volume: 94
• Category: Article
• ISSN: 0007-1323
• DOI: 10.1002/bjs.5934

✦ Synopsis

Sir

Liver failure associated with infections after hepatectomy remains a cause of mortality. It has recently been reported that toll-like receptor 4 (TLR4) is involved in recognizing lipopolysaccharides (LPS). TLR4 mRNA expression in the liver was significantly increased 6 h after hepatectomy; it remained elevated up to 48 h, gradually decreased thereafter, although it remained significantly increased 72 h after partial hepatectomy as compared to sham operated controls 1 . Therefore intravenous injection of a sublethal dose of LPS at 48 h after surgery results in a high mortality 2 . According these findings, we administrated LPS following 48 h after hepatectomy, since TLR4 mRNA was significantly increased and other experimental study previously demonstrated that endotoxin-induced liver failure after hepatectomy occurs at this time point 1 -3 . A