Oncogenic potential is related to activating effect of cancer single and double somatic mutations in receptor tyrosine kinases

METPRC mutations in the ron receptor res

METPRC mutations in the ron receptor result in upregulation of tyrosine kinase activity and acquisition of oncogenic potential

✍ Tracy A. Williams; Paola Longati; Luisa Pugliese; Philippe Gual; Alberto Bardell 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 218 KB 👁 1 views

Ron and Met are structurally related receptor tyrosine kinases that elicit a complex biological response leading to invasive growth. Naturally occurring point mutations activate the Met kinase in papillary renal carcinomas (MET PRC mutations). By site-directed mutagenesis, we generated homologous am