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Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth

✍ Scribed by Gaglio, D.; Metallo, C. M.; Gameiro, P. A.; Hiller, K.; Danna, L. S.; Balestrieri, C.; Alberghina, L.; Stephanopoulos, G.; Chiaradonna, F.


Book ID
118187796
Publisher
Nature Publishing Group
Year
2011
Tongue
English
Weight
887 KB
Volume
7
Category
Article
ISSN
1744-4292

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About 90% of human pancreatic cancers carry K-ras point mutation, which may play an important role in tumorigenesis. We investigated the inhibitory effects of anti-sense oligonucleotides targeting K-ras point mutation on the growth of cultured human pancreatic cancer cells. Eight human pancreatic ca