Oncogenic changes in murine lymphoid tumors induced by in utero exposure to ionizing radiation

✍ Scribed by K. Lumniczky; S. Antal; E. Unger; E.J. Hidvégi; G. Sáfrány

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 221 KB
• Volume: 5
• Category: Article
• ISSN: 1065-7541
• DOI: 10.1002/(sici)1520-6823(1997)5:3<158::aid-roi15>3.0.co;2-2

✦ Synopsis

We have investigated the oncogenic alterations in murine lymphomas induced by in utero exposure to gamma-radiation. The expression of the myc oncogene increased in 23% of the tumors. Alterations in the expression of the ras oncogenes and in the p53 tumor suppressor gene were not characteristic. The p53 gene was mutated in a low percentage of the tumors (12%). Ras mutations were not detected. Loss of heterozygosity (LOH) at the p53 locus was found in 30% of the tumors, and LOH at the mts tumor suppressor gene was detected in 23% of lymphomas. Multiple oncogenic changes were infrequent in the investigated tumors. There were no essential differences in the frequency of carcinogenic alterations in spontaneous and gamma-radiation-induced lymphomas.