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Oncogenes: Growth regulation and the papovaviruses polyoma and SV40

โœ Scribed by Alan E. Smith

Book ID
102878512
Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
788 KB
Volume
26
Category
Article
ISSN
0730-2312

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โœฆ Synopsis

Cellular oncogenes and their activated and retrovirus-coded counterparts play an important role in cellular regulation. Here the relationship between such oncogenes and the genes coding for the transforming proteins of the papovaviruses, polyoma viruses, and simian virus 40 (SV40) is discussed. It is concluded that polyoma virus may transform established cells by a mechanism involving activation of a cellular oncogene product, whereas SV40 may transform by a mechanism involving a previously little studied cytoplasmic form of the transforming protein.

๐Ÿ“œ SIMILAR VOLUMES

Expression of growth-regulated genes in
Expression of growth-regulated genes in normal and SV40 transformed hamster fibroblasts
โœ Ann Marie Krueger Rossi; Ricky R. Hirschhorn ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 862 KB

Transformation by the oncogenic virus SV40 has been shown to alter the expression of cellular genes at the level of RNA abundance. Many of these genes have yet to be identified. We have determined, by Northern blot analysis, the abundance levels of several growth-regulated genes in SV40-transformed