๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Oncogenes as markers for early detection of cancer

โœ Scribed by Geoffrey M. Cooper

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
525 KB
Volume
50
Category
Article
ISSN
0730-2312

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โœฆ Synopsis

Oncogenes are formed in human tumors as a result of mutations or DNA rearrangements leading to the abnormal expression or function of proto-oncogenes. Approximately 20 different oncogenes are reproducibly activated in malignancies of several types, including breast, colon, lung, pancreatic, and thyroid carcinomas, leukemias, and lymphomas. The potential utility of these oncogenes as markers for early detection of cancer is dependent on the stage of tumor development at which they are activated, and on whether the mutated oncogenes are readily distinguished from the corresponding proto-oncogenes by assays that are sufficiently sensitive to detect precancerous lesions.

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