Oncogene Expression in Neurofibromatosis
โ Scribed by PETER T. ROWLEY; BARBARA KOSCIOLEK; JUDITH L. BADER
- Book ID
- 118724144
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 293 KB
- Volume
- 486
- Category
- Article
- ISSN
- 0890-6564
No coin nor oath required. For personal study only.
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An important molecular approach for the Subline Histology Growth-rate Androgen Metatstatic doubling time responsive ability b (days) H Well-differentiated 22 --5 Yes Low HIS Well-differentiated 24 --5 No Low HIM Well-differentiated 9 \_\_\_ 0.8 No Low HIF Moderately differentiated 4.8 --1.8 No Low G
## Abstract The expression of 9 oncogenes in primary tumors and in human tumors passaged in nude mice was tested: a total of 28 tumor types was analyzed. Oncogenes __src, fps__, and __mos__ were not expressed in any of the tumors tested but oncogene __myc__ was transcribed in most of the tumors and
Mouse strains which develop tumors at a high incidence with characteristics very similar to human cancers have been derived over the last 8 years. The tumors are caused by defined genetic alterations in the mouse genome. Three areas of research have contributed to the derivation of these mouse strai