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On the Way to Glycoprocessing Inhibitors − Synthesis of an Imidazolo-Nectrisine-Phosphono Acid Derivative: A Potential Glycosyltranferase Inhibitor

✍ Scribed by Théophile Tschamber; François Gessier; Markus Neuburger; Sudagar S. Gurcha; Gurdyal S. Besra; Jacques Streith


Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
178 KB
Volume
2003
Category
Article
ISSN
1434-193X

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On the Way to Glycoprocessing Inhibitors
✍ Andrzej Frankowski; Dariusz Deredas; Didier Le Nouen; Théophile Tschamber; Jacqu 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 German ⚖ 352 KB

## Abstract An eight‐step synthetic sequence led from the known D‐__xylo__‐pentodialdose 8 to imidazo‐L‐__xylo__‐piperidinose 15, the key steps being the build‐up of imidazole compound 12 by a __van Leusen__ methodology and the intramolecular __S__~N~2 ring closure of the __O__‐triflated benzyliden