On the Unexpected Stereochemical Outcome of the Magnesium in Methanol – Conjugate Reduction of an Exocyclic α,β-Unsaturated Ester

✍ Scribed by Stefan Gabriëls; Dirk Van Haver; Maurits Vandewalle; Pierre De Clercq; Davide Viterbo

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 327 KB
• Volume: 1999
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/(sici)1099-0690(199908)1999:8<1803::aid-ejoc1803>3.0.co;2-l

✦ Synopsis

Analogs of 1α,25-(OH) 2 -vitamin D 3 / Steroids characterized by the absence of a C-ring and by the pres-[a] Department of Organic Chemistry, University of Gent, ence of a conformationally well defined chair six-membered Krijgslaan 281 (S4), B-9000 Gent, Belgium D-ring. In particular analog 4 is designed so as to enforce