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On the two electrophoretic forms of the Human superoxide dismutase A in the homozygote SOD A1

✍ Scribed by N. Crosti


Publisher
Springer
Year
1978
Tongue
English
Weight
193 KB
Volume
16
Category
Article
ISSN
0006-2928

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✦ Synopsis


Human superoxide dismutase A of the common phenotype SOD A1 is present in two electrophoretic forms in erythrocytes. These forms are charge isomers, easily permuting one into the other. Oxidation and reduction of the copper, partial or complete saturation of the dimers with copper, and presence of thiol groups on the enzyme do not seem to be involved.


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## Abstract ## BACKGROUND: Oxidative stress is hypothesized to mediate embryotoxicity during organogenesis, yet the reactive oxygen species involved are not defined. The superoxide oxygen radical is converted to hydrogen peroxide, a less reactive species, by superoxide dismutases (SODs). If supero