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On the Structure of PHB (=Poly[(R)-3-hydroxybutanoic Acid]) in Phospholipid Bilayers: Preparation of Trifluoromethyl-Labeled Oligo[(R)-3-hydroxybutanoic Acid] Derivatives

✍ Scribed by Magnus Rueping; Matthias Albert; Dieter Seebach

Publisher: John Wiley and Sons
Year: 2004
Tongue: German
Weight: 356 KB
Volume: 87
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.200490222

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✦ Synopsis

Abstract

Oligomers of (R)‐3‐hydroxybutanoate (OHB) have previously been shown to transport cations through lipid bilayers. The ion‐transport activity has been attributed to the formation of hydrophobic aggregates or pores, which have been identified by fluorescence‐microscopy measurements of membrane‐incorporated fluorescence‐labeled OHBs. To obtain more information about these aggregates, we describe here the synthesis of the specifically F‐labeled HB oligomers II–IV for structural investigation by means of solid‐state ^19^F‐NMR spectroscopic techniques.

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