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On the structure of lipoamino acids

✍ Scribed by Jul.G. Molotkovsky; L.D. Bergelson

Book ID
103039253
Publisher
Elsevier Science
Year
1968
Tongue
English
Weight
452 KB
Volume
2
Category
Article
ISSN
0009-3084

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✦ Synopsis

Syntheses of I-[(l',2'-distearoyl-glyceryl)-phosphoryl]-3-L-lysyl-glycerol (XII) and l-[(l',2"-distearoyl-glyceryl)-phosphoryl]-2-L-lysyl-glycerol (XX[I), as well as of 1-L-lysyl-3-[(l',2'-distearoyl-glyceryl)-phosphoryl]-glycerol (XVI) are described, the first two substances having the same configuration at all asymmetric atoms as the natural lysyl ester of phosphatidyl glycerol.

It was shown that the a-and fl-lysyl-y-phosphatidyl-glycerols (X[I) and (XXII) differ by their melting points and chromatographic properties and that they do not undergo interconversion on silica gel chromatography in acid or neutral systems. Since synthetic l-[(l'-oleoyl-2'-palmitoyl-glyceryl)-phosphoryl]-3-L-lysyl-glycerol was shown to be chromatographically indistinguishable from the natural lipoamino acid (P. P. M. Bonsen,

πŸ“œ SIMILAR VOLUMES

Synthesis of optical active lipoamino ac
Synthesis of optical active lipoamino acids
✍ L.D. Bergelson; Jul.G. Molotkovsky πŸ“‚ Article πŸ“… 1966 πŸ› Elsevier Science 🌐 French βš– 284 KB

previous studies have shown that the phospholipids of some bacteria contain alanine, &Wine, lysine CP CrnilWh8 in bound form (l-4). Since various investigators had suggested earlier that lipoamino acid complexes may be involved in protein syni-hesis by microorganisms as well as by higher plants and