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On the stereospecific reduction of vinylsulfoxides with thepossibility of deuterium labeling

✍ Scribed by Paula G. Theobald; William H. Okamura

Publisher: Elsevier Science
Year: 1987
Tongue: French
Weight: 285 KB
Volume: 28
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)96914-4

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✦ Synopsis

Upon treating triene sulfoxide 2 or 3 in the presence of methanol (internal proton source> in ether with tert-butyllithium, the reduced product 4b or 4c, respectively, is obtained with retention of configuration.

A deuterium label can be incorporated by using methanol-O-d1 as the internal proton source.

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