✦ LIBER ✦

On the status of the Z-DNA question for animal chromosomes

✍ Scribed by Ronald J. Hill

Publisher: John Wiley and Sons
Year: 1984
Tongue: English
Weight: 768 KB
Volume: 1
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.950010603

No coin nor oath required. For personal study only.

✦ Synopsis

The Z-conformation, recently elucidated in crystals of synthetic alternating dG-dC polymers, is a dramatically different structure for DNA. Despite suggestive locations of alternatingpurinepyrimidine tracts in chromosomes and intriguing functional hypotheses, unequivocal demonstrations of the Z-conformation in vivo are not proving easy. Perhaps the Z-conformation should be considered largely as a dynamic structure transiently forming in torsionally stressed chromatin.

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