On the solution of equations for feel-better hemodialysis

✍ Scribed by C.J. Lee; Y.L. Chang

• Publisher: Elsevier Science
• Year: 1987
• Tongue: English
• Weight: 823 KB
• Volume: 17
• Category: Article
• ISSN: 0010-4825
• DOI: 10.1016/0010-4825(87)90040-0

✦ Synopsis

In this paper, a scheme for "feel better" or optimal hemodialysis (OPTHD) based on a two-compartmental mode1 has been proposed. Contrary to the conventional constant blood flow dialysis (CVTHD), this scheme suggests that the blood flow rate should vary in stages in order to avoid or minimize the disequilibrium syndromes during dialysis. A set of equations for computing the intracellular and extracellular solute concentrations during the OPTHD operation is developed and the computed results are illustrated. Comparing to the CVTHD, the OPTHD has the advantages of operating at a lower and smoother solute concentration difference between compartments for the same length of dialysis time, or it may achieve the same specific degree of blood cleansing within a shorter period of dialysis time. Blood flow Hemodialysis Optimal control Compartment modeling Disequilibrium Syndrome Kinetics Mass transfer Membrane Renal failure Uremia