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On the side-chain conformation of N-acetylneuraminic acid and its epimers at C-7, C-8, and C-7,8

✍ Scribed by Rudolf Christian; Gerhard Schulz; Hannelore H. Brandstetter; Erich Zbiral

Publisher: Elsevier Science
Year: 1987
Tongue: English
Weight: 631 KB
Volume: 162
Category: Article
ISSN: 0008-6215
DOI: 10.1016/0008-6215(87)80195-7

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✦ Synopsis

The side-chain conformation of N-acetylneuraminic acid and analogs has been studied by n.m.r. spectroscopy. The results of the 1H-, 13C-n.m.r.-, and 1H-nuclear-Overhauser-enhancement measurements were used to distinguish between different local-minima conformations suggested by hard-sphere calculations. Attempts were made to correlate the major conformation determined for each compound with the behavior towards activation with N-acetylneuraminic acid-CMP-synthetase.

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