β Scribed by Frederick Harris; Sarah R. Dennison; Jaipaul Singh; David A. Phoenix
No coin nor oath required. For personal study only.
Here, we review potential determinants of the anticancer efficacy of innate immune peptides (ACPs) for cancer cells. These determinants include membraneβbased factors, such as receptors, phosphatidylserine, sialic acid residues, and sulfated glycans, and peptideβbased factors, such as residue composition, sequence length, net charge, hydrophobic arc size, hydrophobicity, and amphiphilicity. Each of these factors may contribute to the anticancer action of ACPs, but no single factor(s) makes an overriding contribution to their overall selectivity and toxicity. Differences between the anticancer actions of ACPs seem to relate to different levels of interplay between these peptide and membraneβbased factors. Β© 2011 Wiley Periodicals, Inc. Med Res Rev
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