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On the selection for the modal chromosome number in Chinese hamster cells

✍ Scribed by M. Terzi

Publisher: John Wiley and Sons
Year: 1972
Tongue: English
Weight: 507 KB
Volume: 80
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1040800306

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✦ Synopsis

Chinese hamster cell lines have a strong tendency to maintain as modal chromosome number the euploid one characteristic of the species. By following the evolution of karyotypes in cloned subpopulation it has been possible to show that these pseudodiploid constitutions are not simply established due to a selective advantage but they are actually generated in populations where pseudodiploid classes had been absent. The possible role of the mitotic apparatus in k;eeping and restoring the euploid number is discussed.

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