✦ LIBER ✦

On the restriction of the release of water-soluble component from polyvinyl alcohol film by blending β-cyclodextrin

✍ Scribed by K. Sreenivasan

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 114 KB
Volume: 65
Category: Article
ISSN: 0021-8995
DOI: 10.1002/(sici)1097-4628(19970829)65:9<1829::aid-app20>3.0.co;2-g

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✦ Synopsis

The effect of adding b-Cyclodextrin with poly(vinyl alcohol) (PVA) hydrogel on the release of a water-soluble component has been investigated. It is found that the release of a model drug, salicyclic acid, from PVA matrix in the presence of b-cyclodextrin prolonged considerably the release of the profile of the drug from the PVA gel. The profound influence of b-cyclodextrin on the drug release has been assigned to the ability of b-cyclodextrin to form an inclusion complex with salicyclic acid.

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