On the reactivity of bromine atoms in brominated pyridines. Preparation of some 2:6-disubstitution products of pyridine
โ Scribed by H. J. den Hertog; J. P. Wibaut
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 793 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0165-0513
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๐ SIMILAR VOLUMES
A recent publication by Dewar and Rxenberg (1) on the bromination and nitration of 4-mct~l-4,~-borazal~o~i~lins (I) has prowted us to report our results on the brcmilution am3 nitration of the thdophene analogue of I, 4-methy1-4,5-borazarothieno(2,3-c]pyridine (IIa; R-C%, R'=Ii). This is only a emal
a b s t r a c t Reaction of 2-bromopyridine with 2 equiv of sodium indazolide in diglyme at 140 ยฐC affords 2,6-bis-(indazol-1-yl)pyridine and 2-(indazol-1-yl)-6-(indazol-2-yl)pyridine in purified yields of 24% and 68% respectively. A similar reaction, using 1 equiv of sodium indazolide at 70 ยฐC, giv