On the reaction of meldrum's acid with N-trimethylsilylanilines substituted by electron withdrawing groups
✍ Scribed by Sandrine Roche; Saïd Yous; Daniel Couturier; Benoît Rigo
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1999
- Tongue
- English
- Weight
- 180 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0022-152X
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
The reaction of Meldrum's acid with silylated anilines substituted by an electron withdrawing group easily yields the corresponding N‐phenyl malonamic acid, when the reaction is performed under high vacuum in dichlorobenzene.
📜 SIMILAR VOLUMES
## Abstract A series of pyrido[2,3‐__d__]pyrimidine‐4,7‐diones 5a‐h were prepared from 6‐amino‐4‐pyrimidones 1 and benzylidene Meldrum's acid derivatives 2 by cyclization reactions in boiling nitrobenzene. The structure of 5, determined by nmr measurements, reveals a selective orientation of 1 and
Aromatic aldehydes or ketones which have electron-withdrawing groups on the benzene ring were selectively reduced to the corresponding alcohols in good yields by sodium hydrogentelluride; common aldehydes such as benzaldehyde and tolualdehyde were inert.